The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant
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چکیده
منابع مشابه
The inhibition of Candida albicans secreted aspartyl proteinase by triangular gold nanoparticles
Objective(s): The aim of this study was to synthesize triangular gold nanoparticles, and then to evaluate their capability for inhibition of Candida albicans secreted aspartyl proteinase 2(Sap2).Materials and Methods: To synthesize the nanoparticles, hydrogen tetrachloroaurate and hexadecyl trimethyl ammonium bromide were incubated in presence of Sn(IV) meso-tetra(N-methyl-4-pyridyl) porphine t...
متن کاملA triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence.
Secreted aspartyl proteinases (Saps) from Candida albicans are encoded by a multigene family with at least nine members (SAP1 to SAP9) and are considered putative virulence factors important for the pathogenicity of this human pathogen. The role of Sap isoenzymes in the virulence of C. albicans has not yet been clearly established, and therefore, using recent progress in the genetics of this ye...
متن کاملSecreted aspartic proteinase family of Candida tropicalis.
Medically important yeasts of the genus Candida secrete aspartic proteinases (Saps), which are of particular interest as virulence factors. Like Candida albicans, Candida tropicalis secretes in vitro one dominant Sap (Sapt1p) in a medium containing bovine serum albumin (BSA) as the sole source of nitrogen. Using the gene SAPT1 as a probe and under low-stringency hybridization conditions, three ...
متن کاملthe inhibition of candida albicans secreted aspartyl proteinase by triangular gold nanoparticles
objective(s): the aim of this study was to synthesize triangular gold nanoparticles, and then to evaluate their capability for inhibition of candida albicans secreted aspartyl proteinase 2(sap2).materials and methods: to synthesize the nanoparticles, hydrogen tetrachloroaurate and hexadecyl trimethyl ammonium bromide were incubated in presence of sn(iv) meso-tetra(n-methyl-4-pyridyl) porphine t...
متن کاملDisruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence.
Secreted aspartyl proteinases (Saps), encoded by a gene family with at least nine members (SAP1 to SAP9), are one of the most discussed virulence factors produced by the human pathogen Candida albicans. In order to study the role of each Sap isoenzyme in pathogenicity, we have constructed strains which harbor mutations at selected SAP genes. SAP1, SAP2, and SAP3, which are regulated differentia...
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ژورنال
عنوان ژورنال: Journal of General Microbiology
سال: 1990
ISSN: 0022-1287
DOI: 10.1099/00221287-136-4-687